Bethany Waddington

Bethany Waddington

Bethany Waddington

PhD student
University of Glasgow

Bethany is a PhD researcher in Dr Thimo Kurz’s lab at the University of Glasgow. Bethany’s project is focussed on creating a more physiologically relevant model for MND.

Her research aims to generate induced pluripotent stem cells from people with a rare genetic cause of the disease, mutations in Ubiquillin 2.  Ubiquillin 2 acts within the Ubiquitin-Proteasome System, aiding clearance of misfolded and aggregated proteins from within the cell. If Ubiquillin 2 is mutated, this degradation pathway is less efficient, resulting in the classical pathology of cellular aggregates and motor neuron death. By generating stem cells derived from people with the mutation, and comparing these to control lines, the mechanistic actions of Ubiquillin 2 within the Ubiquitin-Proteasome System and MND can be better defined.

Outside the lab, Bethany is keen to enhance public engagement in science, especially within her role on the Glasgow Insight into Science and Technology Magazine (TheGIST for short!)

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