Molecular and cellular mechanisms of brain repair

About the project

After brain injury or stroke, human patients often remain disabled for the rest of their lives because the regenerative capacity of the human brain is very limited. In contrast to humans, zebrafish have the ability to repair their brains after injury. Using a combination of in vivo imaging, gene expression profiling and small molecule screens in the optically transparent zebrafish larva, we are now able to study brain repair in real time in a live and intact organism. We hope that gaining insight into the mechanisms underlying the successful brain repair programme of zebrafish will allow us to harness this knowledge for novel therapeutic approaches to brain injury in humans.

Funder(s)

Rosetrees Trust, Wellcome Trust

Publication(s)

Herrgen L, Voss OP, Akerman CJ
Calcium-dependent neuroepithelial contractions expel damaged cells from the developing brain
Dev Cell. 2014 Dec 8;31(5):599-613

Primary location

Edinburgh

Principal Investigator

Other people involved

Collaborations: Prof Catherina Becker, Prof David Lyons, Dr Dirk Sieger

PhD student: Ms Chiara Herzog

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