Edinburgh Brain Bank

About the project

The Edinburgh Brain Bank is a bioresource providing well-characterised human brain tissues to support translational research.

We have donations from patients with detailed clinical information, including ECAS data in many cases, covering the full spectrum of ALS-FTD, including sporadic and familial cases. We also support the array tomography tissue resource overseen by Professor Tara Spires-Jones.

Funder(s)

Target ALS

Publication(s)

Henstridge CM, Sideris DI, Carroll E, Rotariu S, Salomonsson S, Tzioras M, McKenzie CA, Smith C, von Arnim CAF, Ludolph AC, Lulé D, Leighton D, Warner J, Cleary E, Newton J, Swingler R, Chandran S

Gillingwater TH, Abrahams S, Spires-Jones TL

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

Acta Neuropathol. 2018 Feb;135(2):213-226

DOI: 10.1007/s00401-017-1797-4

Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, Pray M, Vasistha NA, Magnani D

Borooah S, Burr K, Story D, McCampbell A, Shaw CE, Kind PC, Aitman TJ, Whitelaw CBA, Wilmut I, Smith C, Miles GB, Hardingham GE, Wyllie DJA, Chandran S

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca(2+)-permeable AMPA receptor-mediated excitotoxicity

Nat Commun. 2018 Jan 24;9(1):347

DOI: 10.1038/s41467-017-02729-0

Primary location

Edinburgh

Principal Investigator

Prof Colin Smith

Other people involved

Professor Tara Spires-Jones

Professor Siddharthan Chandran

Professor Tom Wishart

Professor Seth Grant