Understanding ALS with the Fly

A deep understanding of molecular mechanisms associated with human diseases can lead to the development of therapeutic interventions that are effective, precise and potentially curative. Our laboratory harnesses the power of Drosophila genetics to uncover molecular aspects of ALS pathogenesis with a specific emphasis on a type of ALS known as ALS8.   In particular, we utilize a combination of genetic, molecular, bioinformatics and pharmacological approaches in Drosophila, to identify novel cellular processes important for ALS in humans.  We are currently focussing on the role of lipid droplet metabolism in ALS pathogenesis. Long considered inert deposits of fat, lipid droplets are now recognised to be versatile organelles controlling various physiological processes, such as lipid metabolism, protein homeostasis and viral infections.  The role of lipid droplets in several neurodegenerative diseases, including ALS, is an emerging area of research.